Enhanced antioxidant defense at the cellular level
In reaction to AD, astrocytes experience a shift in profile, one that is reactive and pro-inflammatory while losing homeostatic roles thus disrupting BBB integrity, ion and neurotransmitter buffering, and energy metabolism (Liddelow et al., 2017
Normalization was achieved by dividing the protein/creatinine ratio at day 7 by the ratio before surgery in each group of animals
Cole TA, Zhao H, Collier TJ, Sandoval I, Sortwell CE, Steece-Collier K, Daley BF, Booms A, Lipton J, Welch M, Berman M, Jandreski L, Graham D, Weihofen A, Celano S, Schulz E, Cole-Strauss A, Luna E, Quach D, Mohan A, Bennett CF, Swayze EE, Kordasiewicz HB, Luk KC, Paumier KL (2021) -Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinsons disease
Remember, supplementation works best when all systems are supported