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These interactions involve orexigenic hormones like ghrelin and anorexigenic hormones such as GLP-1, leptin, and peptide YY (PYY) (10)

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The largest increases in first-time CVD diagnosis following first-time GLP-1 RA prescription were seen in the group of people having overweight or BMIs between 27 to 30 (34.5% increase from 2020 to 2024)

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