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Excessive copper levels can cause localized tissue irritation or trigger an inverted, pro-oxidant effect that diminishes your experimental results

The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further

It enhances insulin secretion in response to meals

However, even if you eat enough to get the recommended dose (2.4 micrograms in people 14 and older), older adults and people with gastrointestinal issues may have problems absorbing it properly

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