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These genomic regions are important controllers of gene expression as hypermethylation of the cytosine leads to silencing of gene expression via remodeling of the chromatin structure to favor heterochromatinization (40)

Counts were normalized using the rlog transformation function in DESeq2 (ref

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et al, 2015 (83) showed that Se has a beneficial effect in a cohort of hyperthyroid and Se-deficient patients treated with methimazole and L-T4 under a block-and-replace regimen

Thanks to these activities, it also acts indirectly on the metabolism of carbohydrates and proteins, reducing the use of glucose for energy purposes