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IHS4 is a sum of nodules (multiplied by one), abscesses (multiplied by two), and draining tunnels (multiplied by four), and it permits the classification of the disease severity as mild, moderate, and severe

Arch Biochem Biophys 2013

Let's say a signal goes from neuron A to B

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Contact your GP if you experience persistent or severe gastrointestinal symptoms that interfere with nutrition or hydration, recurrent hypoglycaemia, or any serious adverse effects