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These cell mutations deregulate melanin production, leading to high transfer to keratinocytes and the formation of hyperpigmented or dark spots

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Follow-up question: Thanks for taking the time to reply to my post Lisa

These other things may be whats responsible for the protective effect seen in the 2014 study

This creates a well-documented vicious cycle: stress increases histamine release, histamine amplifies nervous system reactivity (histamine H3 receptors modulate neurotransmitter release, and elevated brain histamine disrupts sleep, worsens anxiety, and heightens stress perception), which in turn drives more stress and further mast cell activation