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Firstly, there is insufficient H 2 O 2 in the acidic tumor microenvironment (TME) (Yu et al., 2023b), and a number of nanoparticles are designed to accelerate the generation of H 2 O 2 near the tumor cell membrane (Zhang et al., 2023a), triggering Fenton/Fenton-like reaction to produce hydroxyl radicals ( OH) and ROS, amplifying the oxidative stress response (Zhang et al., 2023b), and accomplishing ferroptosis within tumor cells

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- Hydration: Ensure adequate hydration to maximize the benefits of both glutathione and collagen, as water is essential for nutrient absorption and cellular function