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However, it is a quite invasive technique, and there is still a lot of uncertainty about the uptake by the brain, which might depend on brain states (e.g., awake vs anesthetized), the hydrophobicity of the compound, or its interaction with efflux transporters (Abbott et al., 2018)

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In spatial planning, the concept has also received increased attention in the past two decades as a planning rationale for designing future-fit spatial structures and planning procedures