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In a rat model of MCAO-induced stroke, neurogenesis was increased by semaglutide treatment, as evidenced by significantly increased levels of neurogenesis-specific biomarkers including nestin (intermediate filament protein that is a known marker of neuronal progenitor cells), doublecortin (microtubule-associated protein considered to be a reliable marker of neurogenesis), stromal cell-derived factor-1 (SDF-1) (chemokine promoting endogenous regeneration in the ischemic brain), and its receptor CXCR4

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Side Effects Side effects can vary, and both medications may include: Nausea Diarrhea Constipation Fatigue or GI discomfort Some users report that side effects diminish with continued use and gradual dose increases, which are common strategies in GLP-1 therapy

The escalation schedule exists precisely so that your GLP-1 receptors can upregulate gradually, your gastrointestinal system can adapt to delayed gastric emptying, and your brain can adjust to new hunger signals

Your health care professional should show you how to take Ozempic before you use it for the first time