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Cytokine Production: GLP-1R activation directly inhibits the production of pro-inflammatory cytokines (TNF-, IL-1, IL-6) and increases anti-inflammatory mediators like adiponectin

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Daily running distances increased by approximately 150% in exercised mice receiving 5-Amino-1MQ treatment, compared to 75% increase in exercise-only groups, with the treatment group maintaining elevated performance more consistently over the 8-week study period

For the 2011 discovery cohort, these samples were obtained during the initial start of the long-term clinical trials conducted by Drs