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We also examined labeling from 13 C-Glc, unexpectedly finding that although glucose was a minor contributor to acetyl-CoA pools in ACLY KO cells, it labeled a much greater fraction, similar to that of palmitate, in DKO cells (Figure 5B)

The HGF levels in serum have been reported to correlate with pancreatic cancer progression in patients [17]

This imbalance induces oxidative stress, which in turn accelerates inflammation and fibrosis progression [315]

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doi: 10.3389/fphar.2018.01162 Received 30 May 2018 Accepted 24 September 2018 Published 16 October 2018 Volume 9 - 2018 Edited by Andres Trostchansky, Universidad de la Repblica, Uruguay Reviewed by Suowen Xu, University of Rochester, United States