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I tried increasing the frequency of SI from 2 weekly to 1 weekly and the flushing got much worse - so I think this is the likely culprit

Limited Long-Term Research There is still limited long-term data on the safety of AOD-9604, especially with extended use

Effects, timing, and any interactions are inferred, not measured

SS-31 addresses the cellular energy consequences Who May Not Be Ideal Candidates Patients expecting immediate dramatic results: SS-31s benefits are cumulative and gradual patients who need immediate energy relief may respond better to NAD+ IV therapy as a faster-acting energy intervention while SS-31 builds longer-term mitochondrial support Patients with budget constraints requiring a single peptide: if only one mitochondrial peptide is in budget, NAD+ typically provides a broader immediate energy response

After receiving the insulin, the subjects were asked to sniff to aid in the delivery of the drug into the nasal cavity