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Klotho mitigates progression of AKI to CKD through activation of autophagy

Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA

PCNA can be targeted and inactivated by p21-derived peptides, including 139164 AA and 144151 AA [54]

Acting as a crucial sensor for assessing the nutritional status of eukaryotic cells, mTOR exhibits activation in response to a surplus of amino acid availability, thereby regulating an assortment of synthetic metabolic pathways essential for sustaining cellular growth [157]

333 Similarly, aggregation-prone proteins, including mutant huntingtin (Htt) and Ataxin-3, disrupt the autophagy machinery in HD and spinocerebellar ataxias, linking impaired autophagy directly to disease progression