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MC1R is expressed on keratinocytes, fibroblasts, dendritic cells, mast cells, and other immune cells in the skin , and MT-1-mediated MC1R activation produces anti-inflammatory effects in these cell types through cAMP-mediated suppression of NF-B activation, reduction of pro-inflammatory cytokine production including TNF-alpha and IL-6, inhibition of reactive oxygen species generation, and modulation of dendritic cell maturation and antigen presentation

Store in a dry, cool place protected from light

It is an analog of angiotensin IV, an oligopeptide, and is orally active and crosses the blood-brain barrier

What it does

However, the clinical significance of TMAO generation from L-carnitine supplementation in humans remains under active investigation, and there is currently no official regulatory warning from the MHRA or EMA specifically prohibiting its use on these grounds