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GIP Receptor Activation Retatrutide also activates GIP receptors, creating a dual-incretin effect

Int Immunopharmacol 101:108174 Hafez HM, Ibrahim MA, Yehia Abdelzaher W, Gad AA, Mohammed Naguib Abdel Hafez S, Abdel-Gaber SA (2021b) Protective effect of mirtazapine against acetic acid-induced ulcerative colitis in rats: Role of NLRP3 inflammasome pathway

It has produced substantial weight reduction in clinical trials, but it remains investigational and is not approved by the FDA or any other regulatory agency as of July 2026

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This treatment category has revolutionized the type 2 diabetes (T2D) space, achieving $20 billion in 2022 T2D sales, led by the success of Novo Nordisks Ozempic and Eli Lillys Mounjaro