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While no significant differences were found in choline, betaine, dimethylglycine, folate, total homocysteine, cystathionine, methylmalonic acid, S-adenosylhomocysteine (SAH), S-adenosylmethionine (SAM), the presence of 11 sphingomyelin species was significantly reduced in patients with prostate cancer as compared to benign hyperplasia (236)
Our observation of a widespread induction of pathways required for viral replication in uninfected cells, in combination with the previous detection of extracellular vesicles containing viral proteins in SARS-CoV-2 infected individuals 62,63 indicate that SARS-CoV-2 infected cells might modulate the permissibility of their microenvironment for viral replication in a similar manner
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The standard curve plasma samples were then stored at -20C and further processed alongside the pharmacokinetic study samples according to the method described above
