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E., Machado-Vieira, R

Yes, caffeine counteracts central fatigue, and decreases the perception of pain and effort during exercise

Common side effects include: Weight gain Nausea or vomiting Diarrhea Asthma or breathing problems Hair whitening or loss Skin rashes Hives or allergic reactions Rare severe reactions like toxic epidermal necrolysis or Steven-Johnson syndrome (with higher doses) Always consult with a qualified practitioner to minimize the risk of side effects

10.1128/EC.00055-15 Eukaryot Cell 55 PasconR

Research use therefore focuses on mechanism, target validation, and combinatorial experiments (e.g., with dietary change or NAD precursors) [14,8,9]