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Moreover, meta-analyses of observational studies have reported that circulating concentrations of vitamin E were significantly lower in AD patients than in cognitively healthy individuals (104, 105)

After obtaining the Cartesian_ddG and Flex_ddG data, variants showing improved stability and binding affinity were manually checked for pAcF orientation

Future research should focus on well-controlled, long-term clinical trials to assess both efficacy and safety

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The required dose is 20 to 40 mg (milligram) per kg body weight of 1 g (gram) to 2 g per day in two divided doses