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Our group has also identified several protective molecules against BBB damage induced by glycation and oxidative stress [72], inflammation [73] and excitotoxicity [74]

Discussion Our concept, which we verified in several previous paper [24, 32, 33, 42], is that if we mimic the specific expression pattern of nutrient transporters at the BBB with a combination of two or three different ligands a more specific targeting of nanoparticles across the BBB can be achieved