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Zinc-deficient animals have been shown to exhibit reduced GPR39 expression in brain areas such as the hippocampus and frontal cortex, similar to observations in humans with depressive symptoms who died by suicide [515]

This may limit the degradation of biological components, such as proteins, DNA and lipids, crucial for membrane integrity, as indicated by markers such as 8-Hydroxy-2-deoxyguanosine (8-OHDG), AMPK activation, and modulation of several other key factors

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10.1164/rccm.202004-0993OC 66

GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice