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Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema
However, development for this purpose was stopped due to side effects, such as severe nausea and increased blood pressure, which limited its clinical usefulness
28 When cellular iron is sufficient, transferrin-bound iron is reduced to limit excess iron accumulation
Mol Genet Metab 2009;96:196-200
BAL fluid, cell lysates, or apical culture supernatants were incubated with glutathione peroxidase (Sigma-Aldrich, G6137), cumene hydroperoxide (Sigma-Aldrich, 247502), glutathione reductase (Sigma-Aldrich, G9297), and NADPH (Sigma-Aldrich, N1630) for 30 minutes at 25C
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