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Yan X, Zhang X, Wang L, Zhang R, Pu X, Wu S, Li L, Tong P, Wang J, Meng Z, Jensen V, Girard L, Minna J, Roth J, Swisher SG , Heymach J, Fang B

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This measurement was used to investigate the efficacy of using 1/10 of the MIC of PZA and INH in controlling M

We demonstrate mechanistically the need for increased mitochondrial function, facilitated by mTORPGC1-mediated mitochondrial biogenesis, to support rebalancing of pyrimidines via UCK2 to support cellular survival in the face of continued 5FU treatment