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Metabolic stressors such as nutrient excess, oxidative stress, and inflammation challenge the proteostasis network by overwhelming the protein-folding capacity of cells and impairing protein degradation systems
J Biol Chem 276:28902897
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Further refinement incorporated astragalus polysaccharides (APS) into colonic site-specific pellets through sustained-release and enteric coatings
In resting state, GSSG/GSH ratio were maintained at lower levels, however, in a cell that is experiencing oxidative stress this ratio shifts toward more GSSG 29
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