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Furocoumarin derivatives increased the number of skin basal layer melanocytes and melanin-containing hair follicles, and upregulated melanin synthesis and TYR activity by activating cAMP/PKA and MAPK signalling pathways [268]

Both groups showed a similar body-weight loss but the pharmacological treated group lost 68% more fat and better maintained lean mass, so this additive effect could be attributed to the pharmacological effect and not to calorie restriction

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1), but only if the samples were run under nonreducing conditions