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Our group reported that bremelanotide is less potent on hMC3R (EC 50 = 5.5 nM, E max = 92%) compared to hMC4R (EC 50 = 0.22 nM, E max = 99%) ( Table 3 ) (25)

L-carnitine is a substance synthesized in the body from the amino acids lysine and methionine and is also obtained from dietary sources such as meat and dairy products

In preclinical models, Dihexa demonstrated superior pharmacokinetic properties, including good oral activity and effective BBB penetration, along with enhanced metabolic stability with a half-life of 335.5 minutes

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Primary Outcomes: Percentage change in body weight