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When Tirzepatide May Not Be Recommended Tirzepatide may not be suitable for individuals with: A personal or family history of medullary thyroid cancer Multiple Endocrine Neoplasia Syndrome Type 2 Pregnancy or plans for pregnancy Certain gastrointestinal disorders A thorough screening ensures that this treatment aligns with your overall health profile

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Furthermore, plasma levels of PCSK5 were significantly elevated in individuals with AMI and in mice post-MI, and markedly lower in Pcsk5 ECKO mice compared to Pcsk5 WT mice post-MI

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