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Front Endocrinol (Lausanne) (2020) 11:623038

The heart benefit and the weight loss benefit appear to operate on different timescales and through different mechanisms

It is essential to emphasize that tirzepatide does not replace thyroid hormone replacement therapy, does not reduce thyroid antibody levels, and does not modify the autoimmune process in Hashimoto's disease

Retatrutide is a synthetic triple agonist peptide targeting glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors simultaneously, representing the next generation of incretin-based research compounds beyond dual agonists

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