Studies also confirmed that exposure of mouse MII oocytes to exogenous H 2 O 2 resulted in the dissipation of mitochondrial membrane potential, a decrease in cytoplasmic ATP levels, and the disruption of meiotic spindles (Zhang et al., 2006)
Open Heart 9:e001989 Doi SA, Al-Zaid M, Towers PA, Scott CJ, Al-Shoumer KA (2005) Irregular cycles and steroid hormones in polycystic ovary syndrome
If cancer is very sensitive to the damaging effects of free radicals, then it might be possible to develop drugs that target cancer cells specifically and prevent them from producing antioxidants or that ramp up free radical levels inside of the malignant cells, exploiting their newly discovered weakness.
Reynolds MR, Lane AN, Robertson B, Kemp S, Liu Y, Hill BG, et al
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