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It is not possible to overdose on the vitamin, as any unused B12 is excreted through the urine

Lower Circulating B12 Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Population Low serum vitamin B-12 and folate concentrations and low thiamin and riboflavin intakes are inversely associated with greater adiposity in Mexican American children Serum concentrations of vitamin B-12 and folate were inversely associated with BMI

PubMed (peer-reviewed) (2024) 3

Apr 2019;213:1-13

This suggests that non-responders were less severely affected by ME/CFS at baseline, and that the main positive effect of nasal B12 administration occurs in more severely affected patients