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Journal of the American Society of Nephrology

Katherine Saunders, obesity medicine specialist at Weill Cornell Medicine, explains: The initial doses of semaglutide are intentionally low to help your body adjust to the medication

Journal of Medicinal Chemistry, 2015, 58(18):7370.DOI:10.1021/acs.jmedchem.5b00726

The Bottom Line Living your best life on a GLP-1 medication means listening to your body

Following administration in phase 1 and phase 2 clinical studies[16]: Time to maximum concentration (Tmax) occurs 12 to 72 hours after subcutaneous injection Dose-proportional pharmacokinetics observed across the therapeutic dose range (1 mg to 12 mg) Steady-state concentrations achieved after approximately 4 weeks of weekly dosing The fatty diacid conjugation enables albumin binding, extending circulation time Systemic exposure increases proportionally with dose escalation Distribution studies indicate widespread tissue distribution following absorption, with concentrations sufficient to engage receptor systems in metabolically relevant tissues including adipose tissue, liver, pancreas, and central nervous system regions involved in appetite regulation