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What weve seen in a real-world setting is those who discontinue particularly early and patients who stay on lower maintenance dosages are quite unlikely to see the weight reductions that are reported in randomized trials

TL;DR: Cleveland Clinics new M6 study on bariatric surgery vs glp-1s published in Nature Medicine on September 16, 2025found that, in people with obesity and type 2 diabetes, metabolic (bariatric) surgery was associated with better long-term survival and fewer heart, kidney, and eye complications than GLP-1 medications alone

Studies show your bodys GLP-1 response can weaken - meaning: Hunger kicks in sooner after meals

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If you have too much, your gut lets you know quickly