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POLG-related disorders should be suspected in patients with a family history or suggestive symptoms of a POLG-related disorder, including but not limited to unexplained encephalopathy, refractory epilepsy (focal, myoclonic), status epilepticus at presentation, developmental delays, psychomotor regression, axonal sensorimotor neuropathy, myopathy cerebellar ataxia, ophthalmoplegia, or complicated migraine with occipital aura

10.1007/430_2013_102 Lewis TJ, Trempe CL, Chapter 7 - Inflammation Friend or Foe?, Editor(s): Thomas J

Biochimica et Biophysica Acta 1783, 589600

Evidence-based treatment combines cognitive behavioral therapy, dialectical behavior therapy, or psychiatric medication