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The first gene strongly associated with psoriasis susceptibility is HLA-Cw6, located at PSORS1 on chromosome 6p21.3 ( 3.1.2.2 Immune factors Interactions between tumor necrosis factor-alpha (TNF-), interferon-gamma (IFN-), and IL-17 induce inflammation and epidermal hyperproliferation ( 3.1.2.3 Environmental factors Beyond genetic predisposition, environmental factors significantly impact the onset, severity, and course of psoriasis ( Ultraviolet (UV) Light: Exposure to UVB radiation, a component of sunlight, is a well-established environmental trigger

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Dont do extreme endurance training if trying to conceive

Go the minimalist route

Exposure to direct sunlight and extreme heat should be avoided