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PMID 14527323

The activation of endothelial cells in association with the fibroblasts may lead to a strengthened skin barrier and increased skin elasticity, as well as potential acceleration in tissue repair

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One very small study found that people who used semaglutide had lower B12 levels, but these patients also had bariatric surgery prior to using semaglutideso its hard to say if using semaglutide would lead to a B12 deficiency, requiring additional B12