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However, the combination of DPP-4i with high-dose angiotensin converting enzyme inhibitors (ACEI) can lead to increased BP

These factors may cause confusion for health care providers when prescribing or dispensing and for patients who are measuring and self-administering these compounded products

Although several agents have entered clinical evaluation, translation into durable clinical benefit remains challenging due to intratumoral heterogeneity, temporal fluctuations in oxygenation (cycling hypoxia), and adaptive resistance mechanisms that bypass single-pathway inhibition

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Betowski J, Rachaczyk J, Wodarczyk M