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However, the most significant difference is between systemic circulation (minutes) and topical application on the skin (hours of local residence time)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Tudor M., Jandric I., Marovic A., Gjurasin M., Perovic D., Radic B., Blagaic A.B., Kolenc D., Brcic L., Zarkovic K., et al