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TB-500s pro-angiogenic effects through endothelial cell migration and tube formation stimulation have been extensively characterised , with research examining how TB-500 drives endothelial cell migration through actin dynamics regulation and ILK/PI3K/Akt signalling, promotes endothelial tube formation in matrigel assays, and stimulates new blood vessel formation in pre-clinical angiogenesis models

The use of ultrasound-guided injections in the study ensured precise delivery of the treatment into the small rabbit knee joint, improving the accuracy and consistency of the intervention