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In summary, we advocate a paradigm shift from Vitamin D nutrition to Vitamin D signaling network regulation, repositioning Vitamin D as a pivotal epidermal signaling node with regenerative and immunomodulatory potential

Propionyl-L-Carnitine Improves Postischemic Blood Flow Recovery and Arteriogenetic Revascularization and Reduces Endothelial NADPH-Oxidase 4Mediated Superoxide Production

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MD simulations on the exendin-P5-bound complex revealed a similar C-terminal interaction pattern to exendin-4 for this peptide, with more persistent interactions with the ECD and TM1/stalk than GLP-1 (Figure 6, Supplemental Figure 11, Supplemental Table 3)