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l-tryptophan is an essential AA, vital for biosynthesis of serotonin (5-HT), melatonin and co-factor NAD + through its downstream metabolic pathways 425

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Sun CL, Hanig JP (1983): Alteration of sensitivity of adrenergic vascular responses after prolonged exposure to agonists via osmotic minipump

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The up-regulation of p53 is positively associated with neuronal apoptosis in the hippocampus of patients with epilepsy [109] and the neuronal death can be evidently blocked by p53 antagonization [110]