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In 1981, a study was published in the International Journal of Clinical Pharmacology, Therapy and Toxicology, detailing the findings of six volunteers who received DSIP intravenously

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doi: 10.1111/j.1526-4637.2009.00613.x PMCID: PMC2891387 NIHMSID: NIHMS209741 Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study Jarred Younger, PhD and Sean Mackey, MD, PhD Clin Rheumatol

Significant weight loss usually begins around 8 to 12 weeks, with patients losing an average of 5% to 10% of their body weight within the first six months of treatment