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Oxaliplatin binds to both erythrocytes and serum albumin: platinum complexes formed via erythrocyte binding have a half-life of up to 1250 days, while agents bound to serum albumin can form a long-term reservoir in the body, continuously releasing free platinum to target tissues such as peripheral nerves, and ultimately mediating chronic cumulative neurotoxicity

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doi: 10.1136/ard.62.8.722 6 CroffordLJ