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Dosage impacts the effectiveness of semaglutide, with most clinical studies on weight loss finding that taking 2.4 mg results in the most weight loss

Documented symptomatic hypoglycemia (glucose of 70 mg/dL or less) was reported in 16.7% to 29.8% of patients receiving semaglutide, and severe or blood glucose confirmed symptomatic hypoglycemia (glucose of 56 mg/dL or less) was reported in 8.3% to 10.7% of patients receiving semaglutide

Higher doses tend to produce faster initial results, but the trajectory of weight loss usually follows a similar curve regardless of starting dose, with the most dramatic losses occurring in the first three to six months

The medication may still be fine, or it may have degraded past the point of effectiveness

Patients perception of injectable therapy include perceived difficultly to use and fear of injections