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Seizure medications: Some anticonvulsants affect B vitamin metabolism

Here, the evidence is less favorable

I think its unlikely well see a massive investment in nutrition research funding that would improve the evidence that supports the guidelines, because we are cutting National Institute of Health funding quite massively

Immunogenicity: No Antibody Formation A critical safety consideration for any peptide therapy is immunogenicity, the potential to trigger immune system responses that could lead to allergic reactions, reduced efficacy through antibody neutralization, or autoimmune complications

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