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In this GLP-1 round up: Oral GLP-1 delivers up to 12.4% weight loss in Phase III trial, offering injection-free alternative High-dose semaglutide achieves 25%+ weight loss in one-third of patients without added safety concerns FDA provides regulatory clarity for muscle-preserving drugs to break through the weight loss plateau WHO issues first recommendation for GLP-1s in obesity, framing it as chronic disease requiring long-term treatment Table of Contents New Drug Formulations and Clinical Trial Data Orforglipron: Phase III Data for Oral GLP-1 Eli Lillys orforglipron, an oral GLP-1 receptor agonist, reported Phase III results from the ATTAIN-1 trial in the New England Journal of Medicine

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