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3b) and comparison with synthetic reference peptides led to the identification of D- O -Leu-D-Ala ( m/z 202.1073, [M-H] ) and L- O -Val-L-Val ( m/z 216.1238, [M-H] ), thus matching the cleavage peptides of cereulides D- O -Leu-D-Ala-L- O -Val-L-Val tetradepsipeptide motif 18

These results suggest that NAFLD is caused by both increased lipid storage (from circulating fatty acid uptake and de novo lipogenesis) and decreased lipid removal (via fatty acid oxidation or VLDL-triglycerides secretion)

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