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IGF-1 exerts protective effects over mitochondria by preserving it from the oxidative damage generated by augmented metabolism, and increasing ATP synthesis and reducing intramitochondrial production of free radicals [105107]
Those on Certain Medications : Some medications, such as metformin (for diabetes) or proton pump inhibitors (for acid reflux), can interfere with B12 absorption
These can be signs of an early B12 deficiency or other nutritional deficiencies like folate, vitamin B2 (riboflavin), and vitamin B3 (niacin) deficiency
Phenotypic manifestations of insulin-like growth factor-binding protein-3 overexpression in transgenic mice
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