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Acarbose (MD 0.55%, 95% CrI 0.83 to 0.28), linagliptin (0.64, 1.11 to 0.15), omarigliptin (0.85, 1.68 to 0.01), sitagliptin (0.91, 1.27 to 0.57), and vildaglipitn (0.53, 0.98 to 0.11) had significant improvements in the HbA1c reduction compared with placebo, such that sitagliptin, omarigliptin, and linagliptin seemed more efficient than acarbose ( n = 7,926) (Figures S5DF)

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48 sessions, 2-3 weeks apart Brightening Mesotherapy Targeted injection of dermatologist-formulated brightening cocktail (TXA, vitamin C, kojic acid, niacinamide) directly into PIH areas addressing the pigmentation at the dermis level where melanin is deposited following the inflammatory acne process

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But they come at a steep cost