Taken together, these pharmacokinetic findings indicate that the centrally mediated effects of GLP-1RAs are likely due to limited brain penetration or action at sites adjacent to the BBB, rather than widespread distribution throughout the central nervous system
Oral semaglutide may cause slightly different nausea patterns because it is absorbed through the stomach lining, while the injection delivers the drug systemically
Liu C, Zou Q, Tang H, Liu J, Zhang S, Fan C
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Bech P, Thomsen J, Prytz S et al (1979) The profile and severity of lithium-induced side effects in mentally healthy subjects