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For example, when using GLS inhibitors to treat PDAC, metabolomic and proteomic analyses showed a significant increase in fatty acid oxidation-related metabolites and proteomics, suggesting a compensatory pathway for glutamine metabolism (Zhang et al., 2013

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This study, a collaboration between the Cancer Epidemiology Unit (CEU) in NDPH, and the International Agency for Research on Cancer (IARC) in Lyon, is the largest and most comprehensive investigation on IGF-1 and cancer risk to date

The precise mechanisms for this effect are unclear

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