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There is also the T(-413)T genotype of rs2071746 , which has been shown to have significantly lower serum bilirubin levels in T(-413)T carriers in both the CRC group and the control group (32)

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In studies of cancers such as HCC (179, 180) and colorectal cancer (181, 182), it has also been found that a high incidence of cancer is correlated with low expression of FABP1, which might be associated with the bilirubin-FABP1 interactions described previously ( Figure 5 )

To determine whether GSH depletion can also exert protective effects in a primarily MASH model, we overexpressed Chac1 in mouse liver using AAV8 followed by challenging mice with methionine/choline-deficient diets (MCDs) to induce MASH